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21 CFR Part 11: Complete Guide to International Computer Validation Compliance for the Pharmaceutical Industry
Lopez, Orlando2004
Introduction Validation Overview What is a Computer System? What is a Computer System Validation? Why Do We Validate Computer Systems? Key Project Elements Which Systems Should be Validated? Introduction to Computer Systems Validation Process Computer Systems Validation for Low Criticality and/or Low Complexity Projects USA Regulatory Requirements for Computer Systems Medical Device Software The Food Industry New Computer Systems Validation Model Computer Validation Management Cycle Computer Validation Program Organization Organizational Model CSV Executive Committee CSV Cross-Functional Team Computer Systems Validation Groups and Teams Management Group Validation Program Coordinators The Computer Systems Validation Process Validation Project Plans and Schedules Regulatory Guidance Validation Project Plans Mandatory Signatures Project Schedule Inspections and Testing Regulatory Guidance Introduction Document Inspections and Technical Reviews White Box Testing Black Box Testing Other Testing Types Qualifications Hardware Installation Qualification Software Installation Qualification System Operational Qualification System Performance Qualification Operating System and Utility Software Installation Verification Standard Instruments, Microcontrollers, Smart Instrumentation Verification Standard Software Packages Qualification Configurable Software Qualification Custom-Built Systems Qualification SLC Documentation Regulatory Guidance SLC Documentation Relevant Procedural Controls Change Management Introduction Change Management Process Training Regulatory Guidance Training in the Regulated Industry Security Regulatory Guidance Introduction Physical Security Network Security Applications Security Other Key Security Elements Source Code Regulatory Guidance All Together Acquisition Process Supply Process Development Process Operation Process Maintenance Process The Future Appendices Appendix A: Glossary of Terms Appendix B: Abbreviations Appendix C: Applicability of New Computer Validation Model Appendix D: Criticality and Complexity Assessment Appendix E: Sample Development Activities by Periods Appendix F: Administrative Procedures Mappe to Part 11 Appendix G: Sample Audit Checklist for a Closed System Appendix H: Computer Systems Regulatory Requirements Appendix I: Technical Design Key Practices
CRC - TAYLOR & FRANCISHISBN: 084932243X   PGS: 264List: 229.95     YOUR PRICE: 218.45
A Guide to Pharmaceutical Particulate Science
Hickey, Anthony2003
INTRODUCTION AND OVERVIEW Situation Analysis Quality of Published Data on Particle Size in Pharmaceuticals The Future of Crystal Engineering Chemistry and Pharmacy Regulatory Submissions Misconceptions and Misunderstandings of Particulate Science Powerful Methods Complementary to Particle Sizing Integration of Particle Sizing Methods with their In-Use Situation Adjacencies and Interactions Between Particles Lessons from Other Industries Pharmaceutical Particulate Science as a Core Educational Requirement Particle Characterization and its Impact on Regulatory Submissions from Formulation through Toxicology and Efficacy Conclusion PARTICULATE SYSTEMS: MANUFACTURE AND CHARACTERIZATION States of Matter Crystalline Solids Crystal Symmetry Euler's Relationship Crystal Systems Miller Indices Space Lattices Solid State Bonding Isomorphs and Polymorphs Enantiomorphs and Racemates Crystal Habit Crystal Imperfections Methods of Particulate Production Particulate Systems Conclusion SAMPLING AND MEASUREMENT BIASES Sampling Strategies Statistical Analyses Sampling Techniques Segregation Sampling Sampling Errors Preparation Errors Particle Size Measurements Errors Conclusions PARTICLE SIZE DESCRIPTIONS AND STATISTICS Particle Size Descriptions Particle Size Statistics Mathematical Distributions Applications Conclusion BEHAVIOR OF PARTICLES Physical Properties Particle Adhesion Particle Motion in Bulk Powders Particle Motion in Gaseous Dispersions Particle Motion in Liquid Media Conclusion INSTRUMENTAL ANALYSIS Direct Imaging Indirect Imaging Physical Methods of Particle Size Separation Approaches to Calibration Conclusions METHODS OF PARTICLE SIZE MEASUREMENT AND THEIR IMPORTANCE FOR SPECIFIC APPLICATIONS (INSTRUMENT SYNERGY) An Essay on Measures of Diameters Conclusion PARTICLE SIZE BEHAVIOR AND PHYSICAL BEHAVIOR OF A POWDER Selection of the Appropriate Particle Size Expression Powder Flow and Mixing Dispersion Granulation and Compression Conclusion CLINICAL EFFECT OF PHARMACEUTICAL PARTICULATE SYSTEMS Oral Delivery Parenteral Delivery Respiratory Delivery Nasal Delivery Transdermal and Topical Delivery Ocular Delivery Otic Delivery Buccal and Sublingual Delivery Rectal Delivery Vaginal Delivery Conclusions GENERAL CONCLUSIONS REFERENCES INDEX
CRC - TAYLOR & FRANCISHISBN: 1574911422   PGS: 256List: 349.95     YOUR PRICE: 332.45
Achieving Sterility in Medical and Pharmaceutical Products:
N. A. Halls1994
The Need for Sterility Sterility and Sterility Assurance Sterilization by Gamma Radiation Sterilization by Saturated Steam Dry Heat Sterilization and Depyrogenation Sterilization by Ethylene Oxide Sterilization by Filtration Aseptic Manufacture Maintenance of Sterility Parametric Release and Other Regulatory Issues
MARCEL DEKKER - TAYLOR & FRANCIS & FRANCHISBN: 0824790146   PGS: 360List: 199.95     YOUR PRICE: 189.95
Advanced Pharmaceutics: Physicochemical Principles
Kim, Cherng-ju2004
THERMODYNAMICS Ideal Gases Real Gases Thermodynamics Free Energy IONIC EQUILIBRIUM Strong Acids and Bases Monoprotic Weak Acids and Weak Bases Polyprotic Weak Acids and Weak Bases Sparingly Soluble Salts SOLUTIONS AND DISTRIBUTION Solutions of Solids and Non-volatile Liquids in Liquids Solutions of Volatile Liquids in Liquids Solutions of Gases in Liquids (Henry's Law) Colligative Properties Distribution Law (Partition Coefficient) SURFACE CHEMISTRY AND COLLOIDS Adsorption from Solutions Liquid-Liquid Systems (Emulsions) Solid-Liquid Systems (Suspensions) KINETICS Pathways of Drug Degradation Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions Irreversible Reactions Determination of the Order of Reaction and Its Rate Constant Other Irreversible Reactions Reversible Reactions Reversible and Series Reactions (Eigenvalue Method) Use of Laplace Transform for Differential Rate Equations Enzyme-Substrate Reactions Acid-Base Catalyzed Degradation Kinetics Oxidation (Free Radical Reaction) Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes Temperature Effects on Reaction Rate Constants DIFFUSION Diffusion Diffusion Through a Membrane Diffusion in a Monolithic Matrix Diffusion in a Membrane-Matrix System Diffusion During the Swelling of Matrix Diffusion in a Matrix Erosion/Degradation Diffusion in a Matrix Swelling/Erosion Diffusion with Chemical Reaction in a Membrane Surface Area and Concentration Gradient Systems Osmotically Controlled Systems POLYMER SCIENCE Classification of Polymers Molecular Weight and Molecular Weight Distribution of Polymers Characterization of Polymers Polymer Synthesis Natural Polymers and Their Modification INDEX
CRC - TAYLOR & FRANCISHISBN: 0849317290   PGS: 512List: 185.95     YOUR PRICE: 176.65
Advances in Controlled Delivery of Drugs
Kohudic, Melvyn1994
Ultrasonically Medicated Drug Delivery Implantable Drug Delivery Polyethylene-Starch Extrudates as Erodible Carriers for Bioactive Materials: I Erodibility and in vitro Dye Release Studies Bioactive Polymers: In vitro and in vivo Study of Controlled Release Neomycin Polymer Entrapment Powders for Topical Delivery Bioactive Polymers 68-Controlled Release of Neomycine-Furazolidone Bicomponent System from Xanthan Hydrogel Effect of Controlled Local Acetylsalicylic Acid Release on in vitro Platelet Adhesion to Vascular Grafts Materials Used in Controlled Release Technology-A Primer
CRC - TAYLOR & FRANCISHISBN: 1566761948   PGS: 154List: 164.95     YOUR PRICE: 156.70
Alcohol and Drug Abuse as Encountered in Office Practice
Iber, Frank L.1990
BACKGROUND. Introduction to Abused Substances. Terminology, Definitions, FDA Classifications, DSM III R Diagnostic Criteria. Molecular Basis of Action of Abused Substances. Etiology of Substance Abuse; Similarities of Alcohol and Drug Abuse. Essential Pharmacology of Abused Drugs. Issues of Law and Custom. Attitudes Among Medical Staff Influencing Substance Abuse Care. SKILLS. Obtaining an Accurate Drug and Alcohol History. Recognition of the Alcoholic and Substance-Abusing Patient in Your Practice. Emergencies in Drug and Alcohol Use and Their Management. Laboratory Use in Screening and Verification of Drug Use. Cost-Effective Screening of Addicted Persons for Significant Illness. Classes of Drugs Needed for the Successful Management of Addiction. Informing the Patient of the Diagnosis of Abuse and Motivating Him to Treatment. SUBSTANCES AND THEIR SPECIFIC PROBLEMS. What Can Be Learned from Smoking and Nicotine Addiction. Alcohol and Sedatives. Medical Problems in Alcoholics. Psychiatric Problems in Addicts. Opium Derivatives. Medical Problems Related to illicit Drugs. Cocaine and Amphetamines. Marijuana. Hallucinogens and Phencyclidine. Miscellaneous Abused Drugs. Mixed Drug Abuse. TREATMENT AND REHABILITATION. What Is Treatment and What Does It Accomplish? Drug Withdrawal: Recognition and Treatment. Entering Treatment. Professionals and Others Providing Skilled Services to Substance Abusers. The Range of Treatment and Rehabilitation Programs: Factors in the Selection of an Appropriate Program. Setting and Meeting Realistic Goals for Rehabilitation. Volunteer Groups in the Treatment of Addictions: The Model of Alcoholics Anonymous. Crises in Treatment. Prevention and Pertinent Public Health Issues. SPECIAL GROUPS. Special Problems of Substance Abuse in Adolescence. Special Problems in Women Abusers. Problems of Addiction During Pregnancy and Problems in the Child. Children of Alcoholics and Drug Abusers. Alcoholism and Addictions in the Elderly. Addictions in Ethnic and Special Social Groups. Abuse in Professionals. Glossary.
CRC - TAYLOR & FRANCISHISBN: 0849301661   PGS: 336List: 195.95     YOUR PRICE: 186.15
Alcohol Interactions with Drugs and Chemicals
Calabrese, Edward J.1991
INTRODUCTION. INORGANICS. CADMIUM. COBALT. HYDROGEN SULFIDE. LEAD. MERCURY. NITROGEN DIOXIDE. ORGANICS. ACETAMINOPHEN. AFLATOXIN. ASPIRIN. Glycine Conjugation. Gastrointestinal Hemmorrhage. BARBITURATES. Possible Mechanisms of the Ethanol-Barbiturate Interaction. Conclusion. BENZENE. BENZO(A)PYRENE. BENZODIAZEPINES. CAFFEINE. CARBON DISULFIDE. CARBON MONOXIDE. CARBON TETRACHLORIDE. Animal Models. Studies with Human Populations. Clinical Studies. Conclusions. CHLORAL HYDRATE. CHLOROFORM. COCAINE. DIMETHYLHYDRAZINE. DIMETHYL SULFOXIDE. DINITROTOLUENE. ETHYLENE GLYCOL AND RELATED AGENTS. ISONIAZID. MENADIONE. METHOMYL. MORPHINE. NITROSAMINES. PESTICIDES. STYRENE. TETRAHYDROCANNABINOL. TOLUENE. TRANQUILIZER COMBINATIONS. 1,1,1-TRICHLOROETHANE. TRICHLOROETHYLENE. VINYL CHLORIDE. VITAMIN A. XYLENE. OTHER: ALDEHYDE DEHYDROGENASE INHIBITORS. SUMMARY.
CRC - TAYLOR & FRANCISHISBN: 0873714032   PGS: 96List: 159.95     YOUR PRICE: 151.95
Allelopathy: Chemistry and Mode of Action of Allelochemicals
Macias, Francisco A.2003
Introduction Reality and Future of Allelopathy, G.R. Waller Chemistry Studies Ecophysiology and Potential Modes of Action for Selected Lichen Secondary Metabolites, J. Romagni, R.C. Rosell, N.P.D. Nanayakkara, and F.E. Dayan Bioactive Compounds from Potomagetonaceae on Aquatic Organisms, M. della Greca, A. Fiorentino, and M. Isidori Fate of Phenolic Allelochemicals in Soils: the Role of Soil and Rhizosphere Microorganisms, U. Blum Benzoxazolin-2(3H)-ones: Generation, Effects, and Detoxification in the Competition Among Plants, D. Sicker, H. Hao, and M. Schulz Heliannanes: A Structure-Activity Relationship (SAR) Study, F.A. Macías, J. C. G. Galindo, and J.M.G. Molinillo Chemistry of the Host-Parasite Interactions, J.C.G. Galindo, F.A. Macías, M.D. Díaz, and J. Jorrín Application of Analytical Techniques to the Determination of Allelopathic Agents in Wheat Root Exudates: A Practical Case Study, T. Haig The Importance of Alkaloidal Functions, M.S. Blum Allelochemical Properties of Quinolizidine Alkaloids, M. Wink Mode of Action Studies Mode of Action of Phytotoxic Terpenoids, S.O. Duke and A. Oliva Mode of Allelochemical Actions of Phenolic Compounds, F. Einhellig Mode of Action of Hydroxamic Acid BOA and Other Related Compounds, A.M. Sánchez-Moreiras, T. Coba de la Peña, A. Martínez, L. González, F. Pellisier, and M.J. Reigosa Mode of Action of Phytotoxic Fungal Metabolites, H.G. Cutler, S.J. Cutler, and D. Matesic Proteomic Techniques for the Study of Allelopathic Stress Produced by Some Mexican Plants on Protein Patterns of Bean and Tomato, R. Cruz-Ortega, T. Romero-Romero, G. Ayala-Cordero, and A.L. Anaya Application of Microscopic Techniques of the Study of Seeds and Microalgae Under Olive Oil Wastewater Stress, G. Alliota, R. Ligrone, C. Ciniglia, A. Pollio, M. Stanzione, and G. Pinto Bioassays: Valuable Tools for the Study of Allelopathy, R. Hoagland and R.D. Williams
CRC - TAYLOR & FRANCISHISBN: 0849319641   PGS: 392List: 154.95     YOUR PRICE: 147.20
Antibiotic Development and Resistance
Hughes, Diarmaid2001
Part 1. The Clinical Context. Part 2. Mechanisms of Antibiotic Resistance. Part 3. Bacterial Genetics and Antibiotic Resistance Dissemination. Part 4. Reversibility of Antibiotic Resistance. Part 5. Development of New Antibiotics.
CRC - TAYLOR & FRANCISHISBN: 0415272173   PGS: N/AList: 164.95     YOUR PRICE: 156.70
AnticoagulantsPhysiologic, Pathologic, and Pharmacologic
Green, David1994
Physiologic Inhibitors: Clinical and Physiological Manifestations of the Protein C Anticoagulant Pathway (C.T. Esmon). Protein S: Clinical and Laboratory Aspects (P.C. Comp). Antithrombin III (M. Manco-Johnson). Tissue Factor Pathway Inhibitor-A Regulator of Tissue Factor Induced Coagulation (M.S. Bajaj, A. Ameri, and S.P. Bajaj). Pathologic Inhibitors: Overview of Factor VIII Inhibitors (J.A. Penner). Immune Tolerance: Historical Perspective and Future Direction (D.M. DiMichele). Inhibitors of Factor VIII in Non-Hemophiliacs (D. Green). The Treatment of Acquired Hemophilia with Porcine Factor VIII Concentrate (C.M. Kessler). Use of Factor IX Complex Concentrates (Prothrombin Complex Concentrates) in Hemophiliacs with Inhibitor Antibodies to Factor VIII or Factor IX (J.M. Lusher). Pathologic Inhibitors (S. Glazer, U. Hedner, J.F. Falch). Lupus Anticoagulants (J.R. Chediak). Acquired von Willebrand's Disease (G.A. Soff). Acquired Inhibitors of Fibrin Stabilization: A Class of Hemorrhagic Disorders of Diverse Origins (L. Lorand). Pharmacologic Inhibitors: Heparin Therapy: Recent Advances in the Treatment of Venous and Arterial Thrombosis (G.F. Pineo, G.E. Raskob, and R.D. Hull). Warfarin Therapy (G.E. Raskob, P.C. Comp, G.F. Pineo, and R.D. Hull). Low Molecular Weight Heparins in the Management of Thrombotic Disorders (J. Fareed, D. Hoppensteadt, J.M. Walenga, W. Jeske, and A. Ahsan). Thrombolytic Therapy-Old and New (H.C. Kwaan).
CRC - TAYLOR & FRANCISHISBN: 0849347629   PGS: 288List: 299.95     YOUR PRICE: 284.95
Antidotes
Flanagan, Robert2001
General Introduction. Agents Used to Treat Poisoning with Metal Ions and Organometallic Compounds. Immunotherapy. Metabolic Antidotes. Pharmacological Antidotes. Antidotes to Carbon Monoxide, Cyanide and Hydrogen Sulphide. Antidotes to Chemical Warfare Agents. Antidotal Treatment of Paraquat Poisoning. Antidote Interference in Toxicological Analyses; Appendix 1: Which Antidote for Which Poison?; Appendix 2: Dosage and Dosage Form of Some Commonly Used Antidotes; Appendix 3: Decision Trees to Aid Treatment of Paracetamol Poisoning; Appendix 4: Guide to the Interpretation of Analytical Toxicology Results and Mass/Amount Concentration Conversion Factors for Some Metals and Trace Elements; Index.
CRC - TAYLOR & FRANCISSISBN: 0748409653   PGS: N/AList: 99.95     YOUR PRICE: 94.95
Antigen Delivery Systems: Immunological and Technological Issues
Gander, Bruno1998
1. Peptide-MHC Complexes Assembled Following Multiple Pathways 2. Antigen Sampling and Presentation in Mucosal Tissues 3. Delivery Systems: The Long Road to Human Vaccine 4. The Choice and Mechanism of Action of Adjuvants 5. Liposomes as Systemic and Mucosal Delivery Vehicles 6. Immune Response 7. Design of Nanoparticles for Vaccine Delivery 8. Mucosal Immunization with Antigen Containing Microparticles 9. Virosomes, a New Liposome-like Vaccine Delivery System 10. Microencapsulation of Antigens for Parenteral Vaccine Delivery 11. Systems Immunological Responses with Biodegradable Polymer Microspheres 12. The Development of Controlled Release Vaccines - The Role of the World Health Organization 13. ISCOMs - Materials, Preparation, Antigen Delivery 14. Pre-clinical Evaluation and Quality Control Aspects of Microparticulate Antigen Delivery Systems
CRC - TAYLOR & FRANCISHISBN: 9057022672   PGS: N/AList: 159.95     YOUR PRICE: 151.95
Antigen Processing and Recognition
McCluskey, James1991
The Biology of Antigen Processing and Presentation (James McCluskey, Rozanne Blok, Andrew Brooks, Weisan Chen, Dawn Kanost, and Lars Kjer-Nielsen). Structure and Function of Major Histocompatibility Complex Molecules (Russel D. Salter). Nature and Specificity of Human Class II Molecule Interactions with Peptide Antigens (Alessandro Sette, Deirdre O'Sullivan, and Howard Grey). Antigen Processing and Presentation by Class I MHC (Andrew J. McMichael, Brigitte A. Askonas, and Jeffrey A. Frelinger). Structural Correlates of MHC Class I Restricted Antigen Specific and Alloreactive Immunity (Sebastian Joyce, Thomas P.J. Garrett, Jan Geliebter, Rui Sun, and Stanley G. Nathenson). The Use of Soluble Proteins to Study Class I-Restricted Processing, Presentation, and T Cell Development (Francis R. Carbone). The Nature of the Ligand Recognized by Alloreactive T Cells (Robert Lechler and Giovanna Lombardi). Is Allorecognition Really Anomalous? (David D. Eckels). The Definition and Expression of Minor Histocompatibility Antigens (Bruce E. Loveland and Kirsten Fischer Lindahl). Bacterial Superantigens (Karin J. Purdie, Keith Hudson and John D. Fraser). Molecular Analysis of the Class II Associated Invariant Chain (Norbert Koch, Ulrich Pessara, Klaus Schenck, and Christopher Wraight). Contribution of Accessory Molecules to MHC/Antigen Presentation: Role of CD2/LFA-3 Interactions in T Cell Recognition of Nominal Antigens (Shigeo Koyasu and Ellis L. Reinherz
CRC - TAYLOR & FRANCISHISBN: 0849369320   PGS: 272List: 359.95     YOUR PRICE: 341.95
Antimicrobial Therapy in Abdominal Surgery: Precepts and Practices
Thadepalli, Haragopal1991
Over the past 50 years, important developments have taken place in surgical and antimicrobial aspects of the management of intestinal surgery and intra-abdominal sepsis. Many new pathogens like Clostridium difficile, Helibacter and Ruminococcus have been described, and many new beta-lactam drugs and quinolones have been introduced. Immunological aspects such as T cell factors and interleukins have been shown to play an important role in the pathogenesis of intra-abdominal sepsis. Important new pieces of surgical hardware, sutures, and surgical glues to salvage solid organs were added to the surgical armanentorium. This new book looks at all of these important developments and more. Over 900 articles were reviewed to synthesize the core information for this book. The editors' years of experience in trauma surgery and intra-abdominal sepsis add to the tremendous amount of information found in this book written for physicians, house-staff, and medical students.
CRC - TAYLOR & FRANCISHISBN: 0849342694   PGS: 120List: 195.95     YOUR PRICE: 186.15
Antimicrobial/Anti-Infective Materials: Principles and Applications
Sawan, Samuel P.1999
PERSPECTIVES ON INFECTIOUS DISEASE CHALLENGES AND ANTIMICROBIAL ANSWERS Antimicrobials Mode of Action and Interaction Host-Parasite Relationship Infectious Disease Challenges Foodborne Diseases and Related Issues Antimicrobial Drug Resistance and Related Issues Rational Use of Antimicrobials Device-Related Infections INFECTIONS OF INTRACARDIAC DEVICES Cardiac Pacemakers Implantable Cardioverter Defibrillators Left Ventricular Assist Devices Prosthetic Cardiac Valves INFECTIONS IN ORTHOPAEDICS Osteomyelitis: Definition, Classification, and Relationship to Orthopaedic Devices Etiology and Establishment of Infections on Orthopaedic Devices Conventional Diagnostic and Treatment Regimens for Osteomyelitis Alternative Approaches to Infection Treatment and Prophylaxis Implant Surfaces That Are Passive and/or Anti-Adhesive Regulatory Issues PHYSIOCHEMICAL BASIS OF BACTERIAL ADHESION TO BIOMATERIAL SURFACES Bacterial Adhesion as a Dynamic Process Properties and Structure of Bacterial Cell Surfaces Non-Specific Adhesion Mechanisms Specific Adhesion Mechanisms Other Factors Affecting Adhesion ALBUMIN AFFINITY COATINGS MAY PREVENT FOREIGN-BODY INFECTIONS Foreign-Body Infections Protein Adsorption Blood Coagulation Fibronolysis Platelet Adhesion Microbial Adhesion Medical-Device Coatings IMMOBILIZED BIOCIDES AS AN ALTERNATIVE STRATEGY FOR CONTROL OF MICROBIAL CONTAMINATION Synthesis of the Immobilized Peptide Systems Biological Activity Chemical and Physical Stability Discussion and Implications ANTI-INFECTIVE COATINGS REDUCE DEVICE-RELATED INFECTIONS Biology on the Surfaces of Indwelling Devices Anti-Infective Medical Devices by Surface Treatment o Further Research REDUCED IMPLANT-RELATED INFECTIOUS COMPLICATIONS BY SURFACE MODIFICATION PROVIDING CONTROLLED ANTIMICROBIAL RELEASE Surface Modification for Controlled Gentamicin Release Animal Studies-Safety and Efficacy Testing A CHEMICALLY INTELLIGENT INFECTION-RESISTANT COATING Anti-Infective Coating Exhibiting Chemical Intelligence Mechanism of Action Coating Stability Bacterial Grow Through Resistance in Coated Microporous Membranes Efficacy Against Biofilms MERGING OF BIOMEDICAL AND TEXTILE TECHNOLOGIES IN ORDER TO CREATE INFECTION-RESISTANT PROSTHETIC VASCULAR GRAFTS Infection of Prosthetic Vascular Grafts Efforts to Combat Graft Infection Textile Dyes Versus Antibiotics: Structural and Chemical Similarities Fluoroquinolone Antibiotics Interaction of Fibers and Small Molecules Application of Fluoroquinolones to Polyester via Pad/Heat Dyeing ASEPTIC APPROACHES AND NOVEL ANTIMICROBIAL CATHETERS FOR PREVENTION OF INFECTION OF VASCULAR CATHETERS Aseptic Approaches Novel Anti-Infective Catheters ANTI-INFECTIVE DEVICES IN OTOLARYNGOLOGY: CURRENT APPLICATIONS AND FUTURE OPPORTUNITIES Otology: Trans-Tympanic Ventilation Tubes Present Examples of Anti-Infective Ventilation Tubes Laryngology: Airway Management Devices and Voice Protheses Rhinology: Nasal Packing, Sinus Stents, and Nasal Septal Buttons LABORATORY METHODS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING: INDICATIONS FOR SUSCEPTIBILITY TESTING Susceptibility Test Methods Special Susceptibility Tests Selection and Reporting of Antimicrobial Agents Emerging Resistance Problems TOWARD DOLLAR DEVICES FOR MEASURING METABOLIC BIOCHEMISTRY A "Simpler" Approach to Bioluminescence-Based Analysis The ATP Platform Substrate Specific Sensors Multi-Analyte Panels Samples Other Technologies SISYPHUS IN THE MICROBIAL WORLD: ANTIMICROBIAL STRATEGIES AND HUMANITY'S HEALTH Role of Science and Technology in Epidemiological Shifts in Human History Multidimensional Antimicrobial Strategies: Coping with the Global Threat of Antimicrobial Resistance Antimicrobial Strategies Through the Lens of the Law Science, Antimicrobial Strategies, and Future Plagues Index
CRC - TAYLOR & FRANCISHISBN: 1566767946   PGS: 346List: 229.95     YOUR PRICE: 218.45
Antioxidants and Disease Prevention
Garewal, Harinder1997
Introduction, H.S. Garewal The Safety of Beta-Carotene and the Antioxidant Vitamins C and E, A.T. Diplock Antioxidants and Immune Function, P.F. Inserra, S.K. Ardestani, and R.R. Watson Antioxidants and AIDS, Z. Ahang, P.F. Inserra, and R.R. Watson Antioxidants and Cancer: The Epidemiologic Evidence, J.W. McLarty Antioxidants and Lung Cancer, S.T. Mayne and R.G. Zeigler Antioxidant Nutrients and Oral Cavity Cancer, H.S. Garewal Selenium and Cancer Prevention, G.F. Combs, Jr. and L. Clark Antioxidants and LDL Oxidation, C.J. Fuller and I. Jialal Antioxidants and Coronary Artery Disease Prevention, R.M. Hoffman and H.S. Garewal Nutritional Antioxidants and Prevention of Age-Related Eye Disease, P.F. Jacques Index
CRC - TAYLOR & FRANCISHISBN: 0849385091   PGS: 208List: 195.95     YOUR PRICE: 186.15
Antisense Research and Applications
Crooke, Stanley T.1993
Introduction. Nucleic Acid Structure and Function. Antisense RNA. Medicinal Chemistry of Oligonucleotides. First Generation Analogs. Newer Analogs. Mechanisms of Action of Current Synthetic Oligonucleotides. Pharmacokinetics and Toxicology. Activities of Current Antisense Drugs. Index.
CRC - TAYLOR & FRANCISHISBN: 084934705X   PGS: 624List: 389.95     YOUR PRICE: 370.45
Antithrombotic Drugs in Thrombosis Models
Hladovec, Josef1989
Introduction. The Rational Basis of Thrombosis Models. Basic Methods. Effects of Antithrombotics and Results of Drug Screening. Drug Combinations. General Conclusions.
CRC - TAYLOR & FRANCISHISBN: 0849351626   PGS: 240List: 319.95     YOUR PRICE: 303.95
APPLIED PHARMACOKINETICS
EVANS1992
APPLIED THERAPEUTICS INCISBN: 0915486156   PGS: N/AList: 91.00     YOUR PRICE: 91.00
Aseptic Pharmaceutical Manufacturing II: Applications for the 1990s
Groves, Michael J.1995
Chapters include: Controlled Environments in the Pharmaceutical & Medical Products Industry: A Global View, R. Dabbah Quality Systems & Total Quality, K. Stephens Aseptic Processing of Healthcare Products, M. Korczynski & J. Lyda Validation of Aseptic Processes, V. Kumar & R. Murty Laboratory Techniques, R. Mehta & R. Murty Aseptic Production: Radiopharmaceuticals, P. Bremer Education & Training of Personnel, M. Akers Predictive Sterility Assurance for Aseptic Processing, C. Sinclair & A. Tallentire Aseptic Processing of Biopharmaceuticals, N. Lugo Lyophilization, E. Trappler Lyophilization Under Barrier Technology, J. Snowman Aseptic Packaging and Labeling, R. Murty Barrier Isolation Technology: A Systems Approach, J. Lysfjord, P. Haas, H. Melgaard & I. Pflug Hydrogen Peroxide Vapor Sterilization: Applications in the Production Environment, L. Edwards & R. Childers Appendix: USP 23 Chapter 1116: Microbiological Evaluation of Clean Rooms and Other Controlled Environments, United States Pharmacopoeial Convention, Inc.
CRC - TAYLOR & FRANCISHISBN: 0935184775   PGS: 540List: 249.95     YOUR PRICE: 237.45
Automation and Validation of Information in Pharmaceutical Processing
Joseph deSpautz1998
Introduction Introduction, Joseph F. deSpautz Systems Planning for Automation Information Systems Planning, Colman O'Murchu Information Technology Planning for Electronic Batch Record Operations, Joseph F. deSpautz Human Factors and Information Systems, James L. Vesper Instrumentation and Process Control System Strategy, David J. Adler Automation Life Cycle Is More than Looking at Cost: It's a New Tool for Competitiveness, Steven B. Williams and David J. Adler Managing the Manufacturing Control Domain, Sean M. Megley Distributed Client/Server-Based Batch Control System Applied as Part of the Enterprise Solution Suite Using Technology, Baha Korkmaz Implementing Automation CIM Architecture for Validated Manufacturing Systems, Joseph F. deSpautz System Implementation Plan for Validated Manufacturing Systems, Joseph F. deSpautz Enhanced Regulatory Compliance Using Manufacturing Execution Systems, Frederick R. Bickel and Richard E. Blanchette Investing in Education and Training, James L. Vesper Documenting Education and Training, James L. Vesper Evaluation and Certification, James L. Vesper Computer Systems Validation GMP Regulations and Computer Validation, Teri Stokes Validation Concepts, Kenneth S. Kovacs and Joseph F. deSpautz Management's Role in Computer Validation: Policy and Procedures, Teri Stokes Electronic Records, Electronic Signatures, and FDA Regulation Final Rule, Teri Stokes Applied Computer Validation Plan for Manufacturing Execution Systems, Frederick R. Bickel and Richard E. Blanchette One Keyboard Pounder's Views on Validation, Joseph A. Hercamp A Validation Plan for Process Automation, Kenneth S. Kovacs and Joseph F. deSpautz Performance Qualification Testing of Integrated MRP/MES, Joseph F. deSpautz and Kenneth S. Kovacs Life Cycle Documentation for MRP-MES-PCS Integration, Joseph F. deSpautz and Kenneth S. Kovacs Supply Chain Automation Research and Development Automation, Jeffrey S. Gramm Plant Design and Engineering, Jack Conaway Logistics, Joseph J. Kowalski Bringing Distributed Control Systems into the World of Client-Server Batch Control, Anthony R. Gonzalez and Mark Castro Batch Process Automation, Teddy H. Tom and Kenneth S. Kovacs
MARCEL DEKKER - TAYLOR & FRANCIS & FRANCHISBN: 0824701194   PGS: 464List: 229.95     YOUR PRICE: 218.45
Autonomic Pharmacology
Broadley, Kenneth J1996
Section 1: Introduction. Anatomy and Physiology of the Autonomic Nervous System. Section 2: Sympathetic NORADRENERGIC Neurones. Sympathetic Neurotransmission. Drugs Affecting Noradrenergic Neurones. Sympathomimetic Amines. Alpha- and Bet-Adrenoceptor Antagonists. Section 3: Cholinergic Neurotransmission. Parasympathomimetic Amines. Muscarine Receptor Antagonists. Anticholinesterases. Drugs Affecting Autonomic Ganglia. Section 4: Non-Adrenergic Non-Cholinergic NANC Neurones. History and Evidence for NANC Neurones. Putative NANC Transmitters. Section 5: Subcellular Mechanisms of Autonomic Receptor Mediated Effects. Alpha-Adrenoceptors and Muscarine Receptors. Beta-Adrenoceptors. Section 6: Experimental Methodology. In Vivo Methods and Models. In Vitro Methods. Receptor Binding Methods.
CRC - TAYLOR & FRANCISHISBN: 0748405569   PGS: N/AList: 299.95     YOUR PRICE: 284.95
Basic Occupational Medicine: A Guide to Developing Delivery Systems
Silver, Robert R.1991
Preface. Introduction. Initial Visit. Follow-Up. Examinations. Critiques. Working with the Physician's Assistant. Working with the In-Plant Occupational Health Nurse. Working with the Consultant: Relationships with the Medical Community. Start-Up and Operation of an Industrial Clinic or Department. Appendix. FEATURES:
CRC - TAYLOR & FRANCISHISBN: 0849342902   PGS: 192List: 195.95     YOUR PRICE: 186.15
BEDSIDE CLINICAL PHARMACOKINETICS: SIMPLE TECHNIQUES FOR INDIVIDUALIZING DRUG THERAPY
PECK1989
APPLIED THERAPEUTICS INCISBN: 0915486105   PGS: N/AList: 11.00     YOUR PRICE: 11.00
Beneficial and Toxic Effects of Aspirin
Feinman, Susan E.1993
Beneficial Effects: History, Uses, Labeling, and Poison Prevention Packaging (B. Bhooshan). Prostaglandins, Other Lipid Mediators, and the Mechanism of Action of Aspirin (A.K. Myers and P.W. Ramwell). Risk: Aspirin Toxicity (S.E. Feinman). Aspirin and Gastrointestinal Toxicity (S.E. Feinman). Aspirin Sensitivity in the Respiratory System (D.D. Stevenson). Aspirin-Related Urticaria and Angioedema (E.J. Bardana, Jr. and A. Montanaro). Benefit-Risk Assessment: The Role of Aspirin in Chemoprevention of Cancer and Its Effect on Mutagenicity (S.E. Feinman). Effects of Aspirin on Female Reproductive Function and on In Utero Development (I. Hertz-Picciotto). Biochemical Manifestations of Reye Syndrome: The Role of Aspirin (L.E. Kilpatrick). Aspirin and the Elderly: Therapeutic Implications (J. Karsh). Veterinary Use and Misuse (T.R.B. Barr). Summary and Conclusions.
CRC - TAYLOR & FRANCISHISBN: 0849372976   PGS: 144List: 249.95     YOUR PRICE: 237.45
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